Publications of R. Kennedy Keller in the field of isoprenoid metabolism (from 1991):

Ness, G.C., Keller, R.K. and Pendleton, L.C. (1991) “Feedback Regulation of Hepatic 3-Hydroxy-3-Methylglutaryl-CoA reductase Activity by Dietary Cholesterol is Not Due to Altered mRNA Levels. J. Biol. Chem. 266, 14854-14857.

Keller, R.K., Cannons, A., Vilsaint, F., Zhao, Z., and Ness, G.C. (1993) “Identification and Regulation of Rat Squalene Synthetase mRNA” Arch Biochem. Biophys. 302, 304-306.

Keller, R.K. and Robert Thompson: Rapid synthesis of isoprenoid diphosphates and their isolation in one step using either thin layer or flash chromatography Journal of Chromatography A, Volume 645, Issue 1, 13 August 1993, Pages 161-167

Keller, R.K. and Vilsaint, F. (1993) “Regulation of Isoprenoid Metabolism in Rat Liver; Near Constant Chain Lengths of Dolichyl Phosphate and Ubiquinone are Maintained During Greatly Altered Rates of Choleterogenesis” Biochim. Biophys. Acta. 1170, 204-210.

Fliesler, S.J., Florman, R., Rapp, L.M., Pittler, S.J., and Keller, R.K. (1993) “In Vivo Biosynthesis of Cholesterol in the Rat Retina” FEBS Lett., 335, 234-238.

Ness, G.C., Zhao, Z., and Keller, R.K. (1994) “Effect of Squalene Synthase Inhibition on the Expression of Cholesterol Biosynthetic Enzymes, LDL Receptor, and Cholest 7 a Hydroxylase” Archives Biochemistry and Biophysics, 311, 277-285.

Fliesler, S.J., Florman, R. and Keller, R.K. (1995) Isoprenoid lipid metabolism in the retina: dynamics of squalene and cholesterol incorporation and turnover in frog rod outer segment membranes Exp. Eye Res. 60, 57-69.

Fliesler, S.J. and Keller, R.K. (1995) “Metabolism of [3H]Farnesol into Cholesterol and Cholesterol Precursors in the Living Rat Eye” Biochem. Biophys. Res. Comm. 210, 695-702.

Pittler, S.J., Fliesler, S.J., Fisher, P., Keller, R.K., and Rapp, L.M. (1995) “In Vivo Requirement of Protein Prenylation for Maintenance of Retinal Cytoarchitecture and Photoreceptor Structure” J. Cell Biol. 130, 431-439.

Keller, R.K., Bangalore, P., Robert, J. and Swanson, M. (1996) Capillary Zone Electrophoresis of Isoprenoid Pyrophosphates J. Chromatography 737 325-331.

Keller, R.K., Chambers, C. and Ness, G.C. (1996) Farnesol is not the Nonsterol Regulator Mediating HMG-CoA Reductase in Rat Liver Arch. Biochem. Biophys. 328, 334-340.

Keller, R.K. (1996) Squalene synthase inhibition alters metabolism of nonsterols in rat liver Biochim. Biophys. Acta 1303, 169-179.

Fliesler, S.J., Boesze-Battaglia,K. Paw, Z., Keller, R.K. and Albert, A.D. (1997) Squalene is localized to the plasma membrane in bovine retinal outer segments Exp. Eye Res. 64, 279-282.

Hoffmann, G. F., Wiesmann, U.N., Brendel, S., Keller, R.K., and Gibson, K.M. (1997) ARegulatory adaptation of isoprenoid biosynthesis and the LDL-Receptor pathway in fibroblasts from patients with mevalonate kinase deficiency Pediatric Research, 41, 541-546.

Sobreira, C., Hirano, M., Shanske, S., Keller, R.K., Haller, R.G., Davidson, E., Santorelli, F.M., Miranda, A.F., Bonilla, E., Mojon, D.S., Barreira, A.A., King, M.P., DiMauro, S. (1997) Mitochondrial encephalomyopathy with coenzyme Q10 deficiency Neurology, 48, 1238-1243.

Swanson, M.G., Robert, J.M., Keller, R.K., and Bangalore, P. (1997) 31P NMR Studies of Isoprenoid Polyphosphate Acid-Base Equilibria Magnetic Resonance in Chemistry, 35, 447-450.

Hinson, D.D., Chambliss, K.L., Hoffmann, G.F., Keller, R.K., and Gibson, K.M. (1997) Identification of an Active Site Alanine in Mevalonate Kinase Through Characterization of a Novel Mutation in Mevalonate Kinase Deficiency. J. Biol. Chem. 272, 26756-26760.

Fliesler, S.J. and Keller, R. K. (1997) Isoprenoid Metabolism in the Vertebrate Retina. Int. J. Bichem. Cell Biol. Vol 29, No. 6, pp 877-894.

Lopez D, Chambers CM, Keller RK, Ness GC (1998) Compensatory responses to inhibition of hepatic squalene synthase. Arch Biochem Biophys 1998 351,159-66.

Keller, R. K. and Fliesler, S.J. (1999) Mechanism of Aminobisphosphonate Action: Characterization of Alendronate Inhibition of the Isoprenoid Pathway, Biochem Biophys Res Commun 266, 560-563.

Keller RK, Arnold TP, Fliesler SJ. (2004) Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome. J Lipid Res. 45(2):347-55.

Keller RK, Small M, Fliesler SJ. (2004) Enzyme blockade: a nonradioactive method to determine the absolute rate of cholesterol synthesis in the brain. J Lipid Res. 45(10):1952-7.

Book Chapter: Adair, W.L. and Keller, R.K. “Isolation and Assay of Dolichol and Dolichyl Phosphate” Methods in Enzymology 111, 201-215.